I like the 357 better, but I figure whatever advantages it offers are outweighed by keeping my game gun and my defense gun the same. I'm a big fan of the "shoot what you carry and carry what you shoot" philosophy.
.45ACP. My EDC is a Springfield XD .45 Compact, IWB holster, with an extra 13 round magazine in a belt pouch, 24 rnds total. But I also have a Glock 19 that I carry on occasion.
Although I will never love a gun more than my Colt 1911 series 70, it is often not practical for me to carry. I often find myself in situations where open carry or partial concealment are not options for me. Therefore I carry a .380 most of the time. It packs enough firepower to get me out of a situation I don't want to be in. That is all I need from a SD weapon. I practice with it faithfully with the goal of every improving speed and accuracy. We can debate calibers all day but any round on target is better than a miss.