Depending on what I'm wearing and how quickly I need to get out of the house, it's either a S&W 360 .357 in a pocket holster or a G19 in a King Tuk. Now that I'm back out in the field visiting clients in a suit, I may need to find a good pocket holster for my P3AT as well...
Once I get all the paper work done it will be a S&W 39-2. Only CF handgun I have to better than nothing.