If you are not going to carry and just want a gun for home, you may want a full-sized pistol rather than the P365. Don't get me wrong, they are great guns. I have one and they shoot great, but why pick a compct gun made for concealed carry when a small gun is not needed and a larger gun may be easier to shoot, hold more ammo, etc.
Glocks are good guns, but I do not care for the ergonomics. I prefer the S&W M&P. As mentioned above, go to the range and rent several guns to see what works best for you and your wife. Consider percieved recoil, ease of slide manipulation, ergonomics, grip size for your hand, and any other characteristic you deem important. Also, you might want to consider a revolver. I am a big fan of revolvers. Once you can shoot a DA revolver well, there's pretty much no such thing as a bad trigger. They also lend themselves to dry-fire practice better than anything out there, and no slide to worry about racking. Just some suggestions that I thought may help. Good luck.
Glocks are good guns, but I do not care for the ergonomics. I prefer the S&W M&P. As mentioned above, go to the range and rent several guns to see what works best for you and your wife. Consider percieved recoil, ease of slide manipulation, ergonomics, grip size for your hand, and any other characteristic you deem important. Also, you might want to consider a revolver. I am a big fan of revolvers. Once you can shoot a DA revolver well, there's pretty much no such thing as a bad trigger. They also lend themselves to dry-fire practice better than anything out there, and no slide to worry about racking. Just some suggestions that I thought may help. Good luck.