Interesting. I know they say to take it at night as that is when cholesterol is formed or absorbed or whatever. But in the last couple years I have had nighttime foot pain that I think has multiple causes including spinal stenosis and borderline type II diabetes. I think I will switch mine and see what happens.Only reaction has been cramping at night over the last few years. Started taking my 20 mg in the AM instead of PM and the problem has resolved.