I have a Ruger 22/45 lite love it, if you have a 1911 you will love the it
I have to echo DIRTROAD's comment. I added fiber optic sights to mine and it is one awesome and accurate gun. One word of caution though, the disassembly is fairly easy. It's the re-assembly that will make you cry!
Browning Buckmark is nice as well as the Ruger MK series. A friend of mine has a S&W M&P .22 pistol. That seems nice too plus if you ever want to get a 9mm it will feel the same as the .22!
I have Ruger MKII. It is nice. Shoots well, built well and not hard to clean. Two or three times stripping it down with an instruction sheet and you will be able to do it blindfolded.
Don't let others scare you about field or even detail stripping a firearm. If you have some mechanical skills, you will be able to do it.
And if you are going to own firearms, you should be able to do that kind of work.
I have a couple of friends with a Buckmark and it seems to be far less picky on ammo.