Never heard anything bad about the Sig Pros (unlike the P250s).
If I was in the market for a polymer SIG, that's what I'd get. Go for it!
Too bad they aren't compatible with other P-series magazines.
+1 on the Magazines, I've got a P250C also and would have been nice to have just one kind of Mag.
As for problems with the 250? I've not had one issue with mine, I rather like the DAO for a carry piece. Mine is a Newer style with the P-Rail, but don't know if they made any other changes/improvements. So far I'm very Happy with mine and Stripping it down is the easiest thing ever!
A plus side for me is, both guns (SP2022 and P250) can share a holster. Not at the same time though