While this may have worked on something in the past for you, making a blanket statement such as this for all the products on the road is a joke(at best).
Sort of... larger flow rate injectors + larger volume pump + TUNE
That last one is the most important.
There is nothing else you would need to change on the vast majority of cars on the road today.
In fact, some cars could run E85 with only a tune. It all depends on what your current injector duty cycle is (preferably @ wide open throttle). Same with the fuel pump.
So for example if your injectors and fuel pump were only at 60% duty at wide open throttle (unlikely, just an example), you could tune in the additional 30% needed to run E85 and be ready to go.
Someone else mentioned being able to run E85 safely with no modification to the car as long as you were easy on it because the O2 sensor will adjust everything for you. This is true. By tuning in the additional 30% needed when installing large injectors and pump, we are essentially doing the same thing; just permanently instead of waiting for the O2 sensor and ECU to do it for us.
Keep in mind though that factory O2 sensors are not wideband sensors except for in the most expensive / performance production cars. So while it is okay to use E85 in a pinch and take it easy until you can get gasoline, you should not just start running E85 all the time and rely on the O2 sensor and ECU to work things out for you. It isn't accurate enough and your injectors and pump likely cannot handle it unless you never exceed a certain throttle percentage (and it would be a low percentage compared to 100% WOT). All it would take is one slip up where you forget, and you floor it and hit WOT. BOOM! One bad enough knock and you're rebuilding that engine.